Using VAAST to Identify Disease-Associated Variants in Next-Generation Sequencing Data.
نویسندگان
چکیده
The VAAST pipeline is specifically designed to identify disease-associated alleles in next-generation sequencing data. In the protocols presented in this paper, we outline the best practices for variant prioritization using VAAST. Examples and test data are provided for case-control, small pedigree, and large pedigree analyses. These protocols will teach users the fundamentals of VAAST, VAAST 2.0, and pVAAST analyses.
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ورودعنوان ژورنال:
- Current protocols in human genetics
دوره 81 شماره
صفحات -
تاریخ انتشار 2014